Learn about side effects, warnings, dosage, and more. Mefenamic acid is used to relieve mild to moderate pain, including menstrual pain pain that happens before or during a menstrual period. It works by stopping the bodys production of a substance that causes pain, fever, and inflammation. Mefenamic acid ingestion, usually in excess and over prolonged period is known to produce interstitial nephritis, or less commonly papillary necrosis, with acute renal failure 1. Aug 20, 2019 mefenamic acid oral capsule is a prescription drug used to treat mild to moderate pain and dysmenorrhea menstrual pain. Know ponstan 50 mg suspension uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug. The structures of all synthesized compounds were confirmed by means of infrared, proton magnetic resonance and mass spectroscopy. Ponstan 50 mg suspension uses, dosage, side effects. Pharmaceutical suspension may be defined as a coarse dispersion containing finely divided insoluble material suspended in a liquid medium. Mefenamic acid side effects, dosage, interactions drugs. Stepwise use of additives for improved control over. Paracetarnol is one of the most popular nonprescriptive analgesics, antipyretic drug. Extract a quantity of the capsule contents or powdered tablets containing 0.
Mefenamic acid dosing, indications, interactions, adverse. Mefenamic acid 250 mg tablet is a nonsteroidal antiinflammatory nsaid medicine used to treat pain associated with conditions like gout, rheumatoid arthritis, sprains of muscles and joints etc. Pdf the bioavailability and pharmacokinetics of mefenamic. Know mefenamic acid 250 mg tablet uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose. It is also used to relieve pain and cramps during menstrual periods. Mefenamic acid ma and paracetamol pc in suspension. Mefenamic acid ethanol alcohol mefenamic acid suspension contains small amounts of. The infrared absorption spectrum is concordant with the reference spectrum of mefenamic acid. Mefenamic acid is also used to treat menstrual pain.
Mefenamic acid is used shortterm 7 days or less to treat mild to moderate pain in adults and children who are at least. Mefenamic acid 250 mg tablet uses, dosage, side effects. Extreme high moderate low section 1 chemical product and company identification product name mefenamic acid statement of hazardous nature considered a hazardous substance according to osha 29 cfr 1910. Mefenamic acid can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Formulation and evaluation of mefenamic acid emulgel for.
Mefenamic acid is licensed for use in children and it is available in specific paediatric formulations oral liquids in eu. Ponstan 50 mg suspension is a nonsteroidal antiinflammatory nsaid medicine used to treat pain associated with conditions like gout, rheumatoid arthritis, sprains of muscles and joints etc. Mefenamic acid oral capsule is a prescription drug used to treat mild to moderate pain and dysmenorrhea menstrual pain. The bioavailability and pharmacokinetics of mefenamic acid. Although classed as a nonsteroidal antiinflammatory drug, its antiinflammatory properties are considered to be minor. See what others have said about mefenamic acid, including the effectiveness, ease of use and side effects. Mefenamic acid works by reducing hormones that cause inflammation and pain in the body. The influence of gelling agent and penetration enhancers was investigated. Mefenamic acid, an anthranilic acid derivative, is a member of the fenamate group of nonsteroidal antiinflammatory drugs nsaids. An offwhite suspension with typical aroma and taste. Mefenamic acid is a nonsteroidal antiinflammatory drug. Mefenamic acid is widely seud by practising pediatricinas. Even people without heart disease or risk factors could have a stroke or heart attack while taking this medicine.
Introduction the suitable formulation for the synthesized drugs is always a challenge for the researchers. A new selfemulsifying formulation of mefenamic acid with. Mefenamic acid is used shortterm 7 days or less to treat mild to moderate pain in adults and children who are at least 14 years old. Composition containing mefenamic acid in association with codeine download pdf. The aim of this research was to study the dissolution profile of mefenamic acid from its solid dosage forms caplet and capsule available in the indonesian market with three different dissolution medium. Mefenamic acid is a member of the anthranilic acid derivatives or fenamate class of nsaid drugs, and is used to treat mild to moderate pain, including menstrual pain, and is sometimes used to prevent migraines associated with menstruation. Development and validation of a liquid chromatographic. Mefenamic acid is well known antiinflammatory agent. Dec 21, 2016 a method of introducing different additives at different times during the process, i. The method has been applied for the analysis of drugs in suspension. In the absence of additives, at optimized conditions, mef crystals were prepared in the size range of 0.
Dissolution profile of mefenamic acid solid dosage forms in. Mefenamic acid united states pharmacopeia usp reference standard synonym. Development and validation of stability indicating hptlc. In patients with renal or hepatic impairment, clearance of metabolites may be decreased. Mefenamic acid oral ponstel side effects, medical uses.
Synthesis and analgesic activity of narylhydrazone. The chemical structure of paracetamol and mefenamic acid is shown in. A proportional investigation safila naveed 1, fatima qamar, syeda sarah abbas1,2, sadia safdar 1, sana ameer and ummeshah idrees1 1faculty of pharmacy, jinnah university for women, karachi, pakistan. Mefenamic acid is typically prescribed for oral administration. The proposed method was found to have linearity in concentration range of 10100. A method of introducing different additives at different times during the process, i. Pdf formulation and characterization of taste masked oral suspension of mefenamic acid and paracetamol by ion exchange resin method. Each bluebanded, ivory capsule contains 250 mg of mefenamic acid for oral administration. This is not a complete list of possible side effects. Feb 14, 2016 the aim of this research was to study the dissolution profile of mefenamic acid from its solid dosage forms caplet and capsule available in the indonesian market with three different dissolution medium. Nov 09, 2018 mefenamic acid is a nonsteroidal antiinflammatory drug nsaid. The retention times of dicyclomine hydrochloride, mefenamic acid and paracetamol were 3. Pdf development of taste masked oral suspension of mefenamic. Mefenamic acid decreases inflammation and uterine contractions by a stillunknown mechanism.
You may also know it better by one of its brand names, mefic or ponstan, which are the names given to the medication made by each pharmaceutical company for marketing purposes. Available on line journal of chemical and pharmaceutical. Dissolution profile of mefenamic acid solid dosage forms. The following conditions are contraindicated with this drug. The aim of this work was to develop an emulgel formulation of mefenamic acid, a hydrophobic drug, using carbopol 940 as gelling agent and two types of penetration enhancer, i. Pdf molecular recognition and solubility of mefenamic. Mefenamic acid is an aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3dimethylphenyl group. Stepwise use of additives for improved control over formation. Usp, pprc, and biorelevant fasted simulated small intestinal fluid fassif media. Estimation and analysis of mefenamic acid suspension. Feb 14, 2017 ponstel mefenamic acid is a nonsteroidal antiinflammatory drug that exhibits antiinflammatory, analgesic, and antipyretic activities in animal models. Learn how to use mefenamic acid, and its dosage, warnings, sideeffects, and more. Pdf physical and chemical characterization of mefenamic acid in. Design and synthesis of new mefenamic acid derivatives as.
According to the british pharmacopoeia 2002 2 and indian pharmacopoeia 6, mefenamic acid in capsule and tablet preparations are identified by examination using infrared absorption spectrophotometry as the following procedure. Mefenamic acid is the generic name of the drug, which is the name of the active component that has an effect on your body. Know mefenamic acid 250 mg tablet uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug. Wo1997006801a1 composition containing mefenamic acid in. Find patient medical information for mefenamic acid oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. A suspension containing mefenamic acid and codeine phosphate. They do not treat the disease that causes those symptoms. Gastrosparing novel prodrugs mam and mat synthesized consisted of mefenamic acid ma with menthol m and thymol t.
A series of narylhydrazone derivatives of mefenamic acid a known nonsteroidal antiinflammatory drug were synthesized in order to obtain new compounds with potential analgesic and antiinflammatory activity. Halflife 5 times longer in preterm infants compared with adults. The compatibility of all the components including pharmaceutical active ingredients plays significant role in designing the. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid. The mechanism of action is mefenamic acid binds the prostaglandin synthetase receptors cox1 and cox2, inhibiting the action of prostaglandin synthetase. What should i discuss with my healthcare provider before taking mefenamic acid ponstel. The results of the determination of the mefenamic acid suspension preparation under the trade name pondex was 100,390,21%, trade name omestan was 99,980,33% and trade name novastan was. Mefenamic acid in plasma was assayed by high performance liquid chromatography. Ponstel mefenamic acid is a nonsteroidal antiinflammatory drug that exhibits antiinflammatory, analgesic, and antipyretic activities in animal models. Buy original ponstan mefenamic acid suspension 60 ml for rs.
Estimation and analysis of mefenamic acid suspension symbiosis. The mah holds the licence for mefenamic acid in the following preparations. Ponstel mefenamic acid side effects, images, uses, dosage. Mefenamic acid is a white to greyishwhite, odorless, microcrystalline powder with a melting point of 230231c and water solubility of. Paracetamol and mefenamic acid suspension, 60ml, for. It is found to be highly effective in controlling high fever.
Feb 14, 2017 where can i get more information ponstel. Check with your physician if you have any of the following. Mefenamic acid suspension is used for mild to moderate pain, painful inflammation of joints, pain associated with menstrual cramps, pain menstrual bleeding primary dysmenorrhea, or abnormally heavy bleeding at menstruation menorrhagia. Similar to other nsaids, mefenamic acid inhibits prostaglandin synthetase.
Mutual prodrug, mefenamic acid, suspensions, dissolution, preformulation. Mefenamic acid united states pharmacopeia usp reference. Mefenamic acid ponstel is an oral drug used shortterm to treat pain, including menstrual cramps. The bioavailability and pharmacokinetics of mefenamic acid was studied in alloxandiabetic rabbits. The mechanism of action of ponstel mefenamic acid, like that of other nsaids, is not completely understood but may be related to prostaglandin synthetase inhibition. Available on line journal of chemical and pharmaceutical research. Mefenamic acid is a nonsteroidal antiinflammatory drug nsaid. This method was also used to study the stability profile of mefenamic acid in tablets for 5 years and suspension for 4 years. According to the pharmacopoeia of the peoples republic of china 7, the method of identification testing of mefenamic acid in capsule and tablet preparations is based on light absorption spectrophotometry.
Mefenamic acid api manufacturers suppliers drug master. However, stop taking mefenamic acid and immediately seek medical attention if you notice any of the following symptoms of a serious allergic reaction. Mefenamic acid is in a class of medications called nsaids. Mefenamic acid plus paracetamol suspension is a highly useful combination for the treatment of moderate. It is an antipyretic, analgesic and antiprostaglandin antiinflammatory drug. Mefenamic acid suspension contains mefenamic acid which is a nonsteroidal antiinflammatory drug nsaid. Sep 23, 2015 mefenamic acid ponstel is an oral drug used shortterm to treat pain, including menstrual cramps. Mefenamic acid suspension 50 mg5 ml mefenamic acid ethanol alcohol mefenamic acid suspension contains small amounts of ethanol alcohol, less than 100 mg per 5 ml. Aug 22, 2011 the aim of this work was to develop an emulgel formulation of mefenamic acid, a hydrophobic drug, using carbopol 940 as gelling agent and two types of penetration enhancer, i.